%PDF-1.5 %?1 0 obj <> endobj 2 0 obj <>/Metadata 112 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /P <> BDC q 1 0 0 1 94.75 35.44999695 cm q 205.5 0 0 -50 0 50 cm /X1 Do Q Q EMC /P <> BDC q 1 0 0 1 371 28.19999695 cm q 117.34999847 0 0 -50.60000229 0 50.60000229 cm /X2 Do Q Q EMC /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 22.98600006 l -90 22.98600006 l h W n BT /FAAAAJ 9 Tf 1 0 0 -1 0 9.56900024 Tm 0 g [( )] TJ ET Q EMC q 1 0 0 1 90 72 cm /P <> BDC BT /FAAABC 22 Tf 1 0 0 -1 33.95500183 23.11899948 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.03500366 54.8769989 Tm /GS2 gs 0 g [(UB)1(B)] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 141.56100464 54.8769989 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABC 22 Tf 1 0 0 -1 318.26501465 54.8769989 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 78 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(UBB)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 83.78500366 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 167.78500366 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 111.53900146 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(UBB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.16000366 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.53399658 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.73600006 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.11000061 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.08999634 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.46400452 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.93800354 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 145.07800293 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140005>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0015000A>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 178.61700439 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016001700180019000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 212.15600586 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 240.09500122 cm /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 268.03399658 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(101-2)1(29)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.4750061 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.84899902 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.73001099 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.10400391 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 322.60598755 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 324.98001099 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 333.7210083 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 336.09500122 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 366.06201172 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 368.43600464 12.55799961 Tm [(UBB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 386.5960083 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 296.97299194 cm /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 324.9119873 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 352.85101318 cm /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 380.79000854 cm q /GS2 gs 1 g 0.375 0.75 m 101.92500305 0.75 l 101.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 102.92500305 -0.25 l 102.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 102.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 102.67500305 16.35000038 l h f* Q q 1 0 0 1 102.30000305 0 cm -0.625 -0.25 m 324.875 -0.25 l 324.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ubiquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.68099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.18099976 11.72200012 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.82799911 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 101.92500305 0.75 l 101.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 102.92500305 -0.25 l 102.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 102.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 102.67500305 16.35000038 l h f* Q q 1 0 0 1 102.30000305 0 cm -0.625 -0.25 m 324.875 -0.25 l 324.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P0CG47)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.0530014 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 101.92500305 0.75 l 101.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 102.92500305 -0.25 l 102.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 102.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 102.67500305 16.35000038 l h f* Q q 1 0 0 1 102.30000305 0 cm -0.625 -0.25 m 324.875 -0.25 l 324.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(09)-1(30)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 101.92500305 0.75 l 101.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 102.92500305 -0.25 l 102.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 102.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 102.67500305 16.35000038 l h f* Q q 1 0 0 1 102.30000305 0 cm -0.625 -0.25 m 324.875 -0.25 l 324.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 101.92500305 0.75 l 101.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 102.92500305 -0.25 l 102.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 102.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 102.67500305 16.35000038 l h f* Q q 1 0 0 1 102.30000305 0 cm -0.625 -0.25 m 324.875 -0.25 l 324.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 101.92500305 0.75 l 101.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 102.92500305 -0.25 l 102.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 102.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 102.67500305 16.35000038 l h f* Q q 1 0 0 1 102.30000305 0 cm -0.625 -0.25 m 324.875 -0.25 l 324.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 101.92500305 0.75 l 101.92500305 203.55000305 l 0.375 203.55000305 l h f* Q q -0.625 -0.25 m 102.92500305 -0.25 l 102.92500305 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 105.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.29199982 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 102.67500305 0.75 m 426.17498779 0.75 l 426.17498779 203.55000305 l 102.67500305 203.55000305 l h f* Q q 1 0 0 1 102.30000305 0 cm -0.625 -0.25 m 324.875 -0.25 l 324.875 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(ubiquitin,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.04200745 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.54200745 11.72200012 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.91600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.41600037 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.25799561 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.75799561 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.25900269 11.72200012 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.93299866 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.43299866 11.72200012 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.51000977 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.01000977 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.48300171 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.98300171 11.72200012 Tm [(kn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ow)1(n)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.54000092 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.04000092 27.3220005 Tm [(Ub)1(iquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.89399719 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.39399719 27.3220005 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.0759964 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.5759964 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.5510025 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.0510025 27.3220005 Tm [(major)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.02100372 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.52100372 27.3220005 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.18099976 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.68099976 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.62199402 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.12199402 27.3220005 Tm [(ta)1(rgeting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.80000305 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.30000305 27.3220005 Tm [(ce)-1(llular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.06199646 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.56199646 27.3220005 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.03500366 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.53500366 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.81298828 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 297.31298828 27.3220005 Tm [(deg)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(rad)1(atio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.15800095 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.65800095 42.92200089 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.16999817 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.66999817 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.67099762 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.17099762 42.92200089 Tm [(26)-1(S)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.92099762 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.42099762 42.92200089 Tm [(pro)1(teosome.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.102005 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.602005 42.92200089 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.60099792 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.10099792 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.66200256 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.16200256 42.92200089 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.41900635 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.91900635 42.92200089 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.28799438 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.78799438 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.72900391 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.22900391 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.23001099 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.73001099 42.92200089 Tm [(maintenan)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.61999989 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.11999989 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.96199989 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.46199989 58.52199936 Tm [(chromat)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.3769989 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.8769989 58.52199936 Tm [(st)1(ruc)-1(ture,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.5 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.00100708 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.50100708 58.52199936 Tm [(regulat)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.73199463 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.23199463 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.07400513 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.57400513 58.52199936 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.08999634 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.58999634 58.52199936 Tm [(expression,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.70999146 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.20999146 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.48699951 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.98699951 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 314.98800659 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(st)1(re)-1(ss)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.3939991 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.8939991 74.12200165 Tm [(response.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.05799866 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.55799866 74.12200165 Tm [(Ub)1(iquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.41200256 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.91200256 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.47299957 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.9730072 74.12200165 Tm [(synthesized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.29899597 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.79899597 74.12200165 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.94000244 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.44000244 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.41499329 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.91499329 74.12200165 Tm [(precu)-1(r)1(sor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.02600098 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.52600098 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.83300781 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.33300781 74.12200165 Tm [(consis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.0510006 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.5510006 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.39299965 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.89300156 89.72200012 Tm [(either)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.83200073 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.33200073 89.72200012 Tm [(po)1(l)-1(yubiq)1(u)-1(it)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.64099884 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.14099884 89.72200012 Tm [(chains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.2769928 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.7769928 89.72200012 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.93499756 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.43499756 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.41000366 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.91000366 89.72200012 Tm [(single)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.2749939 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.7749939 89.72200012 Tm [(ubiquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.45599365 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.95599365 89.72200012 Tm [(moiety)] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.72900391 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.22900391 89.72200012 Tm [(fused)] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.92401123 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.07499981 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.57499981 105.3219986 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.09600067 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.59600067 105.3219986 Tm [(unre)-1(la)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.81700134 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.31700134 105.3219986 Tm [(pro)1(tein)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.79000092 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.29000092 105.3219986 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.55200195 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.05200195 105.3219986 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.56799316 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.06799316 105.3219986 Tm [(consists)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.09500122 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.59500122 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.43699646 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.93699646 105.3219986 Tm [(th)1(re)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.48100281 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.98100281 105.3219986 Tm [(direct)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.54199219 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.04199219 105.3219986 Tm [(repeats)] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.93301392 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.43301392 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.2749939 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.0010004 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.50099945 120.92199707 Tm [(ubiquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.18199921 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.68199921 120.92199707 Tm [(coding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.3710022 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.8710022 120.92199707 Tm [(seque)-1(nce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.71800232 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.21800232 120.92199707 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.61399841 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.11399841 120.92199707 Tm [(no)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.38200378 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.88200378 120.92199707 Tm [(spa)1(c)-1(er)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.82699585 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.32699585 120.92199707 Tm [(seque)-1(nce)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.34100342 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.84100342 120.92199707 Tm [(Consequen)-1(t)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(y,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.92999983 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.43000031 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.43099976 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.93099976 136.52200317 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.23799896 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.73799896 136.52200317 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.2990036 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.7990036 136.52200317 Tm [(expressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.95300293 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.45300293 136.52200317 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.59399414 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.09399414 136.52200317 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.06900024 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.56900024 136.52200317 Tm [(po)1(l)-1(yubiq)1(u)-1(it)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.87800598 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.37800598 136.52200317 Tm [(precu)-1(r)1(sor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.48899841 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.98899841 136.52200317 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.38500977 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.88500977 136.52200317 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.85998535 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.35998535 136.52200317 Tm [(final)] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.79098511 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 310.29098511 136.52200317 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(mino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.09600067 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.59600067 152.12199402 Tm [(acid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.23600006 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.73600006 152.12199402 Tm [(af)1(ter)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.72699738 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.22699738 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.22799683 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.72799683 152.12199402 Tm [(last)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.61699677 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.11699677 152.12199402 Tm [(repeat.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.00900269 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.50900269 152.12199402 Tm [(An)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.38699341 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.88699341 152.12199402 Tm [(ab)1(e)-1(rr)1(ant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.46299744 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.96299744 152.12199402 Tm [(fo)1(rm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.67399597 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.17399597 152.12199402 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.01600647 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.51600647 152.12199402 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.97198486 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.47198486 152.12199402 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.7789917 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 297.2789917 152.12199402 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.96099854 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.50699997 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.00699997 167.72200012 Tm [(detected)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.05899811 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.55899811 167.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.5 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81 167.72200012 Tm [(pa)1(tien)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.64199829 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.14199829 167.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.53799438 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.03799438 167.72200012 Tm [(Alz)1(he)-1(imer's)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.68299866 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.18299866 167.72200012 Tm [(disease)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.85400391 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.35400391 167.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.6309967 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.1309967 167.72200012 Tm [(Do)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.35998535 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.85998535 167.72200012 Tm [(syndro)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 183.32200623 Tm [(me.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.70600033 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.20599937 183.32200623 Tm [(Pseudog)1(e)-1(nes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.69100189 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.19100189 183.32200623 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.03299713 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.53299713 183.32200623 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.98899841 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.48899841 183.32200623 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.00500488 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.50500488 183.32200623 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.022995 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.522995 183.32200623 Tm [(located)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.34399414 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.84399414 183.32200623 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.11199951 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.61199951 183.32200623 Tm [(chromos)1(ome)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.57299805 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.07299805 183.32200623 Tm [(1,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.51699829 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.01699829 183.32200623 Tm [(2,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.46099854 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.96099854 183.32200623 Tm [(13)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.68301392 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 198.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.27700043 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.77700043 198.92199707 Tm [(17)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.49900055 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.99900055 198.92199707 Tm [(Alt)1(e)-1(rna)1(tive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.72200012 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.22200012 198.92199707 Tm [(splicin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.13700104 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.63700104 198.92199707 Tm [(results)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.80599976 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.30599976 198.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.24699402 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.74699402 198.92199707 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.1190033 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.6190033 198.92199707 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.54100037 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.04098511 198.92199707 Tm [(var)1(i)-1(a)1(n)-1(t)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.77700806 198.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 301.6499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 102.30000305 0.75 m 102.30000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 102.30000305 17.10000038 m 102.30000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 102.30000305 33.45000076 m 102.30000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 102.30000305 49.80000305 m 102.30000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 102.30000305 66.15000153 m 102.30000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 102.30000305 82.5 m 102.30000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 102.30000305 98.84999847 m 102.30000305 301.6499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 301.6499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 302.0249939 m 426.92498779 302.0249939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ?? 丰满少妇被猛烈进入,丰满女老板BD高清,日韩国产成人无码AV在线,日本免费人成在线观看网站 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