%PDF-1.5 %?1 0 obj <> endobj 2 0 obj <>/Metadata 118 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /P <> BDC q 1 0 0 1 94.75 35.44999695 cm q 205.5 0 0 -50 0 50 cm /X1 Do Q Q EMC /P <> BDC q 1 0 0 1 371 28.19999695 cm q 117.34999847 0 0 -50.60000229 0 50.60000229 cm /X2 Do Q Q EMC /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 22.98600006 l -90 22.98600006 l h W n BT /FAAAAJ 9 Tf 1 0 0 -1 0 9.56900024 Tm 0 g [( )] TJ ET Q EMC q 1 0 0 1 90 72 cm /P <> BDC BT /FAAABC 22 Tf 1 0 0 -1 33.95500183 23.11899948 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.09400177 54.8769989 Tm /GS2 gs 0 g [(UB)1(E2B)] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 152.5019989 54.8769989 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABC 22 Tf 1 0 0 -1 329.20599365 54.8769989 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 78 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.25 12.82499981 Tm [(UBE2B)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 99.48300171 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 183.48300171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 111.53900146 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(UBE2B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.60800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.98200226 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.18399811 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.55799866 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.53799438 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.91200256 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.38600159 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 145.07800293 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(HR6B;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.08599854 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.45999908 12.82499981 Tm [(UBC2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.63800049 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.01200104 12.82499981 Tm [(HHR6B;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.63999939 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.01400757 12.82499981 Tm [(RAD6B;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.09300232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.46699524 12.82499981 Tm [(E2-17kDa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.03700256 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 178.61700439 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 212.15600586 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 273.63400269 cm /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 301.57299805 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.15999985 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.5340004 12.55799961 Tm [(length)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.6609993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.03499985 12.55799961 Tm [(fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.3259964 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.69999695 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.08200073 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 330.51199341 cm /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 358.45098877 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 386.39001465 cm /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 414.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 132.125 0.75 l 132.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 133.125 -0.25 l 133.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.875 16.35000038 l h f* Q q 1 0 0 1 132.5 0 cm -0.625 -0.25 m 294.67498779 -0.25 l 294.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ubiquitin-)1(c)-1(onjugat)1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.08699799 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.58699799 11.72200012 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.96800232 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.46800232 11.72200012 Tm [(E2B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.34100342 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 132.125 0.75 l 132.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 133.125 -0.25 l 133.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.875 16.35000038 l h f* Q q 1 0 0 1 132.5 0 cm -0.625 -0.25 m 294.67498779 -0.25 l 294.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(HR6)-1(B;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.9279995 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.4279995 11.72200012 Tm [(UBC2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.25899887 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.75899887 11.72200012 Tm [(HH)-1(R6B)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.64800262 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.14800262 11.72200012 Tm [(RA)1(D6)-1(B;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.30299377 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.80299377 11.72200012 Tm [(E2-17)-1(kDa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.20799255 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 132.125 0.75 l 132.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 133.125 -0.25 l 133.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.875 16.35000038 l h f* Q q 1 0 0 1 132.5 0 cm -0.625 -0.25 m 294.67498779 -0.25 l 294.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P63)-1(14)-1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 132.125 0.75 l 132.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 133.125 -0.25 l 133.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.875 16.35000038 l h f* Q q 1 0 0 1 132.5 0 cm -0.625 -0.25 m 294.67498779 -0.25 l 294.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(05)-1(97)-1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 132.125 0.75 l 132.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 133.125 -0.25 l 133.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.875 16.35000038 l h f* Q q 1 0 0 1 132.5 0 cm -0.625 -0.25 m 294.67498779 -0.25 l 294.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 132.125 0.75 l 132.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 133.125 -0.25 l 133.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.875 16.35000038 l h f* Q q 1 0 0 1 132.5 0 cm -0.625 -0.25 m 294.67498779 -0.25 l 294.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 132.125 0.75 l 132.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 133.125 -0.25 l 133.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.875 16.35000038 l h f* Q q 1 0 0 1 132.5 0 cm -0.625 -0.25 m 294.67498779 -0.25 l 294.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 132.125 0.75 l 132.125 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 133.125 -0.25 l 133.125 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.875 0.75 m 426.17498779 0.75 l 426.17498779 156.75 l 132.875 156.75 l h f* Q q 1 0 0 1 132.5 0 cm -0.625 -0.25 m 294.67498779 -0.25 l 294.67498779 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(mod)1(i)-1(f)1(ic)-1(at)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.63200378 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.13200378 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.97399902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.47399902 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.9469986 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.44700623 11.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.84300232 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.34300232 11.72200012 Tm [(ubiquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.02400208 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.52400208 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.08500671 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.58500671 11.72200012 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.10600281 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.60600281 11.72200012 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.56698608 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.06698608 11.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.35199928 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.85199928 27.3220005 Tm [(mec)-1(ha)1(n)-1(ism)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.96099854 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.46099854 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.73899841 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.23899841 27.3220005 Tm [(ta)1(rgeting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.91700745 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.41700745 27.3220005 Tm [(ab)1(n)-1(o)1(rmal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.64599609 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.14599609 27.3220005 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.30400085 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.80400085 27.3220005 Tm [(sho)1(rt-)1(li)-1(v)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.29400635 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.79400635 27.3220005 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.26699829 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.27799988 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.77799988 42.92200089 Tm [(degra)1(dat)1(ion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.72299957 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.22299957 42.92200089 Tm [(Ub)1(iquitinatio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.06700134 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.56700134 42.92200089 Tm [(involves)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.34500122 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.84500122 42.92200089 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.17300415 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.67300415 42.92200089 Tm [(least)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.66799927 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.16799927 42.92200089 Tm [(th)1(re)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.71200562 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.21200562 42.92200089 Tm [(cl)-1(a)1(sses)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.69900513 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.19900513 42.92200089 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.11999989 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.61999989 58.52199936 Tm [(en)-1(z)1(y)-1(mes:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.33300018 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.83300018 58.52199936 Tm [(ubiquitin-)1(ac)-1(t)1(ivating)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.39300537 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.89300537 58.52199936 Tm [(en)-1(z)1(y)-1(mes,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.60600281 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.10600281 58.52199936 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.26400757 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.76400757 58.52199936 Tm [(E1s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.32299805 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.82299805 58.52199936 Tm [(ubiquitin-)1(c)-1(onju)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ga)1(ting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.78199959 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.2820015 74.12200165 Tm [(en)-1(z)1(y)-1(mes,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.99500275 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.49500275 74.12200165 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.65299988 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.15299988 74.12200165 Tm [(E2s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.71199799 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.21199799 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.48899841 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.98899841 74.12200165 Tm [(ubiquitin-)1(prot)1(e)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.86999512 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.36999512 74.12200165 Tm [(ligases,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.4960022 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.9960022 74.12200165 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.15400696 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.6539917 74.12200165 Tm [(E3s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.2130127 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.7130127 74.12200165 Tm [(T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(his)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.10299969 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.60300064 89.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.11899948 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.61899948 89.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.53600311 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.03600311 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.01100159 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.51100159 89.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.7749939 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.2749939 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.11700439 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.61700439 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.61799622 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.11799622 89.72200012 Tm [(E2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.34399414 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.84399414 89.72200012 Tm [(ubiquitin-)1(c)-1(onjugat)1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.93099976 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.43099976 89.72200012 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(nzyme)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.27400017 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.77399826 105.3219986 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.02199936 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.52200317 105.3219986 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.78399658 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.28399658 105.3219986 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.66500092 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.16500092 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.72599792 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.22599792 105.3219986 Tm [(required)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.76699829 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.26699829 105.3219986 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.54499817 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.04499817 105.3219986 Tm [(po)1(st-)1(re)-1(p)1(li)-1(cat)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.07501221 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.57501221 105.3219986 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.07998657 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(da)1(mage)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.0019989 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.5019989 120.92199707 Tm [(repair.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.76599884 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.26599884 120.92199707 Tm [(Its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.43099976 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.93099976 120.92199707 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.23799896 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.73799896 120.92199707 Tm [(seque)-1(nce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.58500671 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.08500671 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.64599609 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.14599609 120.92199707 Tm [(10)-1(0%)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.98599243 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.48599243 120.92199707 Tm [(identical)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.92100525 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.42100525 120.92199707 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.4960022 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.9960022 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.99700928 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(mouse,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.13999939 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.63999939 136.52200317 Tm [(rat)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.57099915 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.07099915 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.34799957 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.84799957 136.52200317 Tm [(rab)1(bit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.50299835 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.00299835 136.52200317 Tm [(ho)1(mologs,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.6269989 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.1269989 136.52200317 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.22399902 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.72399902 136.52200317 Tm [(indic)-1(a)1(tes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.92999268 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.42999268 136.52200317 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.6519928 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.1519928 136.52200317 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.60800171 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.10800171 136.52200317 Tm [(en)-1(z)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(yme)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.3029995 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.8029995 152.12199402 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.36400032 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.86399841 152.12199402 Tm [(hig)1(hly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.25799942 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.75800323 152.12199402 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.83499908 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.33499908 152.12199402 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.27600098 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.77600098 152.12199402 Tm [(eu)-1(karyot)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.48599243 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.98599243 152.12199402 Tm [(evolution.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.66099548 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.5 0.75 m 132.5 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.5 17.10000038 m 132.5 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.5 33.45000076 m 132.5 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.5 49.80000305 m 132.5 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.5 66.15000153 m 132.5 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.5 82.5 m 132.5 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.5 98.84999847 m 132.5 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.5 115.19999695 m 132.5 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 271.57501221 m 426.92498779 271.57501221 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ?? 丰满少妇被猛烈进入,丰满女老板BD高清,日韩国产成人无码AV在线,日本免费人成在线观看网站 ͨ| | | Ϊ| | ƽ| ɳ| ̨| ٸ| ״| ˮ| ޼| ǰ| | Ѿ| | | | | | | | | | | ̰| | | | лͨ| Ͻ| | | ׯ| Ͽ| ʯ¥| ԭ| ״| | Զ| | http://444 http://444 http://444 http://444 http://444 http://444