%PDF-1.5 %?1 0 obj <> endobj 2 0 obj <>/Metadata 118 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /P <> BDC q 1 0 0 1 94.75 35.44999695 cm q 205.5 0 0 -50 0 50 cm /X1 Do Q Q EMC /P <> BDC q 1 0 0 1 371 28.19999695 cm q 117.34999847 0 0 -50.60000229 0 50.60000229 cm /X2 Do Q Q EMC /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 22.98600006 l -90 22.98600006 l h W n BT /FAAAAJ 9 Tf 1 0 0 -1 0 9.56900024 Tm 0 g [( )] TJ ET Q EMC q 1 0 0 1 90 72 cm /P <> BDC BT /FAAABC 22 Tf 1 0 0 -1 33.95500183 23.11899948 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.75 54.8769989 Tm /GS2 gs 0 g [(UB)1(E2D3)] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 158.84500122 54.8769989 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABC 22 Tf 1 0 0 -1 335.54901123 54.8769989 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 78 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(UBE2D3)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 100.30400085 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 184.30400085 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 111.53900146 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(UBE2D3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.67900085 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.0530014 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.25500488 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.6289978 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.60899353 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.98300171 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.45700073 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 145.07800293 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(UBC4/5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.55500031 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.92900085 12.82499981 Tm [(UBCH5C;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.2480011 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.62199402 12.82499981 Tm [(E2\(17\)KB3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.57000732 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 178.61700439 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 212.15600586 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 273.63400269 cm /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 301.57299805 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.15999985 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.5340004 12.55799961 Tm [(length)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.6609993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.03499985 12.55799961 Tm [(fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.3259964 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.69999695 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.08200073 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 330.51199341 cm /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 358.45098877 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 386.39001465 cm /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 414.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 97.42500305 0.75 l 97.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 98.42500305 -0.25 l 98.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 98.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 98.17500305 16.35000038 l h f* Q q 1 0 0 1 97.80000305 0 cm -0.625 -0.25 m 329.375 -0.25 l 329.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ubiquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.68099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.18099976 11.72200012 Tm [(conj)-1(ug)1(ating)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.69400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.19400024 11.72200012 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.57499695 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.07499695 11.72200012 Tm [(E2D)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.15699768 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.65699768 11.72200012 Tm [(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.93499756 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 97.42500305 0.75 l 97.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 98.42500305 -0.25 l 98.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 98.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 98.17500305 16.35000038 l h f* Q q 1 0 0 1 97.80000305 0 cm -0.625 -0.25 m 329.375 -0.25 l 329.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(UBC4/)-1(5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.95399857 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.45399857 11.72200012 Tm [(UBCH5)-1(C;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.26599884 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.76599884 11.72200012 Tm [(E2\(1)-1(7\)KB3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.1969986 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 97.42500305 0.75 l 97.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 98.42500305 -0.25 l 98.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 98.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 98.17500305 16.35000038 l h f* Q q 1 0 0 1 97.80000305 0 cm -0.625 -0.25 m 329.375 -0.25 l 329.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P61)-1(07)-1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 97.42500305 0.75 l 97.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 98.42500305 -0.25 l 98.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 98.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 98.17500305 16.35000038 l h f* Q q 1 0 0 1 97.80000305 0 cm -0.625 -0.25 m 329.375 -0.25 l 329.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(03)-1(39)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 97.42500305 0.75 l 97.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 98.42500305 -0.25 l 98.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 98.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 98.17500305 16.35000038 l h f* Q q 1 0 0 1 97.80000305 0 cm -0.625 -0.25 m 329.375 -0.25 l 329.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 97.42500305 0.75 l 97.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 98.42500305 -0.25 l 98.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 98.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 98.17500305 16.35000038 l h f* Q q 1 0 0 1 97.80000305 0 cm -0.625 -0.25 m 329.375 -0.25 l 329.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 97.42500305 0.75 l 97.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 98.42500305 -0.25 l 98.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 98.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 98.17500305 16.35000038 l h f* Q q 1 0 0 1 97.80000305 0 cm -0.625 -0.25 m 329.375 -0.25 l 329.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 97.42500305 0.75 l 97.42500305 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 98.42500305 -0.25 l 98.42500305 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 98.17500305 0.75 m 426.17498779 0.75 l 426.17498779 156.75 l 98.17500305 156.75 l h f* Q q 1 0 0 1 97.80000305 0 cm -0.625 -0.25 m 329.375 -0.25 l 329.375 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(mod)1(i)-1(f)1(ic)-1(at)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.63200378 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.13200378 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.97399902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.47399902 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.9469986 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.44700623 11.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.84300232 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.34300232 11.72200012 Tm [(ubiquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.02400208 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.52400208 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.08500671 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.58500671 11.72200012 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.10600281 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.60600281 11.72200012 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.56698608 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.06698608 11.72200012 Tm [(ce)-1(llular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.82901001 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.32901001 11.72200012 Tm [(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(chanism)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.56900024 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.06900024 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.34700012 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.84700012 27.3220005 Tm [(ta)1(rgeting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.52500153 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.02500153 27.3220005 Tm [(ab)1(n)-1(o)1(rmal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.2539978 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.7539978 27.3220005 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.91200256 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.41200256 27.3220005 Tm [(sho)1(rt-)1(li)-1(v)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.9019928 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.4019928 27.3220005 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.875 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.375 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.65301514 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.15301514 27.3220005 Tm [(degra)1(dat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 2.16700006 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.66699982 42.92200089 Tm [(Ub)1(iquitinatio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.51100159 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.01100159 42.92200089 Tm [(involves)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.78900146 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.28900146 42.92200089 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.61699677 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.11699677 42.92200089 Tm [(least)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.11199951 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.61199951 42.92200089 Tm [(th)1(re)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.15600586 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.65600586 42.92200089 Tm [(cl)-1(a)1(sses)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.14300537 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.64300537 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.48500061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.98500061 42.92200089 Tm [(en)-1(z)1(y)-1(mes:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.69799805 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.19799805 42.92200089 Tm [(ubiquitin-)1(ac)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(tiva)1(ting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.4980011 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.9980011 58.52199936 Tm [(en)-1(z)1(y)-1(mes,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.71099854 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.21099854 58.52199936 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.3690033 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.8690033 58.52199936 Tm [(E1s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.4280014 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.9280014 58.52199936 Tm [(ubiquitin-)1(c)-1(onjugat)1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.01499939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.51499939 58.52199936 Tm [(en)-1(z)1(y)-1(mes,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.22799683 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.72799683 58.52199936 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.88598633 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.38598633 58.52199936 Tm [(E2s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.94500732 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.44500732 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 309.72198486 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 314.22198486 58.52199936 Tm [(u)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(biq)1(u)-1(it)1(in)-1(-)1(prot)1(ei)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.33499908 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.83499908 74.12200165 Tm [(ligases,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.96099854 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.46099854 74.12200165 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.6190033 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.1190033 74.12200165 Tm [(E3s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.67799377 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.17799377 74.12200165 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.44000244 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.94000244 74.12200165 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.45599365 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.95599365 74.12200165 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.8730011 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.3730011 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.3480072 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.8480072 74.12200165 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.11199951 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.61199951 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.45401001 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.95401001 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 308.95498657 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.45498657 74.12200165 Tm [(E)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.27799988 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.77799988 89.72200012 Tm [(ubiquitin-)1(c)-1(onjugat)1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.86499786 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.36499786 89.72200012 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.7460022 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.2460022 89.72200012 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.4940033 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.9940033 89.72200012 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.2559967 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.7559967 89.72200012 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.13699341 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.63699341 89.72200012 Tm [(func)-1(t)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.54400635 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.04400635 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.98498535 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.48498535 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 309.48599243 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.98599243 89.72200012 Tm [(u)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(biq)1(u)-1(it)1(in)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.125 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.625 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46700287 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.96700287 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.96800232 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.46800232 105.3219986 Tm [(tumor)1(-supp)1(re)-1(ss)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.09300232 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.59300232 105.3219986 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.8999939 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.3999939 105.3219986 Tm [(p53)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.86999512 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.36999512 105.3219986 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.4670105 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.9670105 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.52801514 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.02801514 105.3219986 Tm [(induc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.64801025 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 312.14801025 105.3219986 Tm [(b)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.76399994 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.26399994 120.92199707 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.78499985 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.28499985 120.92199707 Tm [(E3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.51100159 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.01100159 120.92199707 Tm [(ubiquitin-)1(prot)1(e)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.89199829 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.39199829 120.92199707 Tm [(ligase.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.352005 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.852005 120.92199707 Tm [(Multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.58399963 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.08399963 120.92199707 Tm [(splice)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.16499329 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.66499329 120.92199707 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.58700562 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.08700562 120.92199707 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.65701294 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.15701294 120.92199707 Tm [(ha)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.83100033 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.33100033 136.52200317 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.83800125 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.33800125 136.52200317 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.02799988 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.52799988 136.52200317 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.80599976 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.30599976 136.52200317 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.76200104 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.26200104 136.52200317 Tm [(gene)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.94400024 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.44400024 136.52200317 Tm [(but)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.09100342 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.59100342 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.59199524 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.09199524 136.52200317 Tm [(full-length)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.13999939 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.63999939 136.52200317 Tm [(nature)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.602005 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.102005 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.94400024 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.44400024 136.52200317 Tm [(some)] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.8710022 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.3710022 136.52200317 Tm [(var)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(nts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.06499958 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.56500053 152.12199402 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.24700165 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.74700165 152.12199402 Tm [(not)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.36800003 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.86800003 152.12199402 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.375 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.875 152.12199402 Tm [(determine)-1(d)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.03799438 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 97.80000305 0.75 m 97.80000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 97.80000305 17.10000038 m 97.80000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 97.80000305 33.45000076 m 97.80000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 97.80000305 49.80000305 m 97.80000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 97.80000305 66.15000153 m 97.80000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 97.80000305 82.5 m 97.80000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 97.80000305 98.84999847 m 97.80000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 97.80000305 115.19999695 m 97.80000305 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 271.57501221 m 426.92498779 271.57501221 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ?? 丰满少妇被猛烈进入,丰满女老板BD高清,日韩国产成人无码AV在线,日本免费人成在线观看网站 | ֱ| ¹| | | ɽ| | ƽ| ˺| ӻ| | | | | ²| | | | | | Ϫ| Ž| ԭ| | Ȩ| | ĵ| 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