%PDF-1.5 %?1 0 obj <> endobj 2 0 obj <>/Metadata 118 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /P <> BDC q 1 0 0 1 94.75 35.44999695 cm q 205.5 0 0 -50 0 50 cm /X1 Do Q Q EMC /P <> BDC q 1 0 0 1 371 28.19999695 cm q 117.34999847 0 0 -50.60000229 0 50.60000229 cm /X2 Do Q Q EMC /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 22.98600006 l -90 22.98600006 l h W n BT /FAAAAJ 9 Tf 1 0 0 -1 0 9.56900024 Tm 0 g [( )] TJ ET Q EMC q 1 0 0 1 90 72 cm /P <> BDC BT /FAAABC 22 Tf 1 0 0 -1 33.95500183 23.11899948 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.67500305 54.8769989 Tm /GS2 gs 0 g [(UB)1(E2G2)] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 158.91999817 54.8769989 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABC 22 Tf 1 0 0 -1 335.62399292 54.8769989 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 78 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.25 12.82499981 Tm [(UBE2G2)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 105.71800232 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 189.71800232 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 111.53900146 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(UBE2G2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.84300232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.21700287 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.41900635 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.79299927 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.772995 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.14700317 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.6210022 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 145.07800293 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(UBC7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.3690033 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 178.61700439 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 212.15600586 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 273.63400269 cm /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 301.57299805 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.15999985 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.5340004 12.55799961 Tm [(length)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.6609993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.03499985 12.55799961 Tm [(fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.3259964 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.69999695 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.08200073 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 330.51199341 cm /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 358.45098877 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 386.39001465 cm /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 414.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 109.625 0.75 l 109.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 110.625 -0.25 l 110.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.375 16.35000038 l h f* Q q 1 0 0 1 110 0 cm -0.625 -0.25 m 317.17498779 -0.25 l 317.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ubiquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.68099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.18099976 11.72200012 Tm [(conj)-1(ug)1(ating)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.69400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.19400024 11.72200012 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.57499695 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.07499695 11.72200012 Tm [(E2G)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.9940033 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.4940033 11.72200012 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.77200317 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 109.625 0.75 l 109.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 110.625 -0.25 l 110.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.375 16.35000038 l h f* Q q 1 0 0 1 110 0 cm -0.625 -0.25 m 317.17498779 -0.25 l 317.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(UBC7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.66500092 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 109.625 0.75 l 109.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 110.625 -0.25 l 110.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.375 16.35000038 l h f* Q q 1 0 0 1 110 0 cm -0.625 -0.25 m 317.17498779 -0.25 l 317.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P60)-1(60)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 109.625 0.75 l 109.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 110.625 -0.25 l 110.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.375 16.35000038 l h f* Q q 1 0 0 1 110 0 cm -0.625 -0.25 m 317.17498779 -0.25 l 317.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(01)-1(73)-1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 109.625 0.75 l 109.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 110.625 -0.25 l 110.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.375 16.35000038 l h f* Q q 1 0 0 1 110 0 cm -0.625 -0.25 m 317.17498779 -0.25 l 317.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 109.625 0.75 l 109.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 110.625 -0.25 l 110.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.375 16.35000038 l h f* Q q 1 0 0 1 110 0 cm -0.625 -0.25 m 317.17498779 -0.25 l 317.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 109.625 0.75 l 109.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 110.625 -0.25 l 110.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.375 16.35000038 l h f* Q q 1 0 0 1 110 0 cm -0.625 -0.25 m 317.17498779 -0.25 l 317.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 109.625 0.75 l 109.625 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 110.625 -0.25 l 110.625 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.375 0.75 m 426.17498779 0.75 l 426.17498779 156.75 l 110.375 156.75 l h f* Q q 1 0 0 1 110 0 cm -0.625 -0.25 m 317.17498779 -0.25 l 317.17498779 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(mod)1(i)-1(f)1(ic)-1(at)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.63200378 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.13200378 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.97399902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.47399902 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.9469986 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.44700623 11.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.84300232 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.34300232 11.72200012 Tm [(ubiquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.02400208 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.52400208 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.08500671 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.58500671 11.72200012 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.10600281 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.60600281 11.72200012 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.56698608 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.06698608 11.72200012 Tm [(ce)-1(llular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.82901001 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(mec)-1(ha)1(n)-1(ism)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.10900116 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.60900116 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.88700104 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.38700104 27.3220005 Tm [(ta)1(rgeting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.06500244 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.56500244 27.3220005 Tm [(ab)1(n)-1(o)1(rmal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.79400635 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.29400635 27.3220005 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.45199585 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.95199585 27.3220005 Tm [(sho)1(rt-)1(li)-1(v)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.44200134 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.94200134 27.3220005 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.41500854 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.91500854 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.19299316 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.69299316 27.3220005 Tm [(degra)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(da)1(tion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.91399956 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.41400146 42.92200089 Tm [(Ub)1(iquitinatio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.25800323 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.75800323 42.92200089 Tm [(involves)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.53599548 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.03599548 42.92200089 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.36399841 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.86399841 42.92200089 Tm [(least)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.85899353 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.35899353 42.92200089 Tm [(th)1(re)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.90299988 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.40299988 42.92200089 Tm [(cl)-1(a)1(sses)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.88999939 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.38999939 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.23199463 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.73199463 42.92200089 Tm [(en)-1(z)1(y)-1(mes:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.44500732 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.94500732 42.92200089 Tm [(ub)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(iquitin-a)1(c)-1(t)1(ivating)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.26599884 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.76599884 58.52199936 Tm [(en)-1(z)1(y)-1(mes,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47899628 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.97899628 58.52199936 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.13699341 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.63699341 58.52199936 Tm [(E1s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.19599915 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.69599915 58.52199936 Tm [(ubiquitin-)1(c)-1(onjugat)1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.78300476 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.28300476 58.52199936 Tm [(en)-1(z)1(y)-1(mes,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.9960022 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.4960022 58.52199936 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 308.6539917 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(E2s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.55900002 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.05900002 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.33599854 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.83599854 74.12200165 Tm [(ubiquitin-)1(prot)1(e)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.71700287 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.21700287 74.12200165 Tm [(ligases,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.34300232 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.84300232 74.12200165 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.00100708 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.50100708 74.12200165 Tm [(E3s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.05999756 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.55999756 74.12200165 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.82200623 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.32200623 74.12200165 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.83799744 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.33799744 74.12200165 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.25500488 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.75500488 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.73001099 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.23001099 74.12200165 Tm [(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(mber)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.72400093 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.22400093 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.06600189 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.56600189 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.56700134 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.06700134 89.72200012 Tm [(E2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.29299927 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.79299927 89.72200012 Tm [(ubiquitin-)1(c)-1(onjugat)1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.88000488 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.38000488 89.72200012 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.76100159 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.26100159 89.72200012 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.50900269 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.00900269 89.72200012 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.81600952 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.31600952 89.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.82299805 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.30699921 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.80699921 105.3219986 Tm [(sha)1(re)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.19800186 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.69799805 105.3219986 Tm [(10)-1(0%)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.53800201 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.03800201 105.3219986 Tm [(seque)-1(nce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.88499451 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.38499451 105.3219986 Tm [(identity)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.05400085 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.55400085 105.3219986 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.94999695 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.44999695 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.45100403 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.95100403 105.3219986 Tm [(mouse)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.92399597 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.42399597 105.3219986 Tm [(coun)-1(t)1(e)-1(r)1(part)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.32501221 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 120.92199707 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.3390007 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.8390007 120.92199707 Tm [(ubiquito)1(usly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.17099762 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.67099762 120.92199707 Tm [(expressed,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.99200439 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.49200439 120.92199707 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.88800049 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.38800049 120.92199707 Tm [(hig)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.6230011 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.1230011 120.92199707 Tm [(expression)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.07699585 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.57699585 120.92199707 Tm [(see)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.50201416 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.00201416 120.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.94299316 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.44299316 120.92199707 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(dult)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.0510006 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.5510006 136.52200317 Tm [(musc)-1(le.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.8769989 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.3769989 136.52200317 Tm [(Three)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.72699738 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.22699738 136.52200317 Tm [(alt)1(e)-1(rnat)1(ive)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.75 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.25 136.52200317 Tm [(splice)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.33099365 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.83099365 136.52200317 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.75300598 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.25300598 136.52200317 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.82299805 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.32299805 136.52200317 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.66500854 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(dist)1(in)-1(ct)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.47800064 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.97800064 152.12199402 Tm [(isof)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.13800049 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.63800049 152.12199402 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.98500061 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.48500061 152.12199402 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.99199677 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.49200439 152.12199402 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.18200684 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.68200684 152.12199402 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.96000671 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.46000671 152.12199402 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.91600037 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.41600037 152.12199402 Tm [(gene)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.0980072 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110 0.75 m 110 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110 17.10000038 m 110 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110 33.45000076 m 110 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110 49.80000305 m 110 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110 66.15000153 m 110 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110 82.5 m 110 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110 98.84999847 m 110 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110 115.19999695 m 110 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 271.57501221 m 426.92498779 271.57501221 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ?? 丰满少妇被猛烈进入,丰满女老板BD高清,日韩国产成人无码AV在线,日本免费人成在线观看网站 | | ɽ| | | | | | | ̩| ֦| ʯ| ϽϽ| | ʲ| | ˮ| Ƹ| ̶| | | ʤ| | ֺ| | | | | | ں| ɳ| | ˮ| ߰| | ױ| ϲ| ¦| ɽ| | | http://444 http://444 http://444 http://444 http://444 http://444