%PDF-1.5 %?1 0 obj <> endobj 2 0 obj <>/Metadata 123 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /P <> BDC q 1 0 0 1 94.75 35.44999695 cm q 205.5 0 0 -50 0 50 cm /X1 Do Q Q EMC /P <> BDC q 1 0 0 1 371 28.19999695 cm q 117.34999847 0 0 -50.60000229 0 50.60000229 cm /X2 Do Q Q EMC /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 22.98600006 l -90 22.98600006 l h W n BT /FAAAAJ 9 Tf 1 0 0 -1 0 9.56900024 Tm 0 g [( )] TJ ET Q EMC q 1 0 0 1 90 72 cm /P <> BDC BT /FAAABC 22 Tf 1 0 0 -1 33.95500183 23.11899948 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.18000031 54.8769989 Tm /GS2 gs 0 g [(UB)1(E2V1)] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 158.41499329 54.8769989 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABC 22 Tf 1 0 0 -1 335.11898804 54.8769989 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 78 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(UBE2V1)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 99.8010025 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 183.80099487 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 111.53900146 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(UBE2V1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.1760025 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.55000305 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.7519989 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.12600708 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.10600281 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.47999573 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.95399475 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 145.07800293 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CIR1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.07700348 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.4509964 12.82499981 Tm [(UEV1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.40399933 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.77799988 12.82499981 Tm [(CROC1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.75999451 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.13400269 12.82499981 Tm [(UBE2V;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.79800415 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.17199707 12.82499981 Tm [(UEV-1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.33900452 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.71299744 12.82499981 Tm [(UEV1A;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.74099731 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.11500549 12.82499981 Tm [(CROC-)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.50201416 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 178.61700439 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 212.15600586 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 273.63400269 cm /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 301.57299805 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.15999985 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.5340004 12.55799961 Tm [(length)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.6609993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.03499985 12.55799961 Tm [(fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.3259964 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.69999695 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.08200073 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 330.51199341 cm /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 358.45098877 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 386.39001465 cm /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 414.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 98.92500305 0.75 l 98.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 99.92500305 -0.25 l 99.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 99.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 99.67500305 16.35000038 l h f* Q q 1 0 0 1 99.30000305 0 cm -0.625 -0.25 m 327.875 -0.25 l 327.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ubiquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.68099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.18099976 11.72200012 Tm [(conj)-1(ug)1(ating)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.69400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.19400024 11.72200012 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.57499695 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.07499695 11.72200012 Tm [(E2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.30099487 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.80099487 11.72200012 Tm [(var)1(i)-1(a)1(n)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.20500183 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.70500183 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.98300171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 98.92500305 0.75 l 98.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 99.92500305 -0.25 l 99.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 99.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 99.67500305 16.35000038 l h f* Q q 1 0 0 1 99.30000305 0 cm -0.625 -0.25 m 327.875 -0.25 l 327.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CIR1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.98600006 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.48600006 11.72200012 Tm [(UE)1(V)-1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.68399811 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.18399811 11.72200012 Tm [(CROC1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.8789978 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.3789978 11.72200012 Tm [(UBE2V)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.22399902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.72399902 11.72200012 Tm [(UE)1(V)-1(-)1(1)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.81599426 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.31599426 11.72200012 Tm [(UE)1(V)-1(1A;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.84700012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.34700012 11.72200012 Tm [(CROC-)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.76899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 98.92500305 0.75 l 98.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 99.92500305 -0.25 l 99.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 99.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 99.67500305 16.35000038 l h f* Q q 1 0 0 1 99.30000305 0 cm -0.625 -0.25 m 327.875 -0.25 l 327.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q13)-1(40)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 98.92500305 0.75 l 98.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 99.92500305 -0.25 l 99.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 99.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 99.67500305 16.35000038 l h f* Q q 1 0 0 1 99.30000305 0 cm -0.625 -0.25 m 327.875 -0.25 l 327.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(00)-1(46)-1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 98.92500305 0.75 l 98.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 99.92500305 -0.25 l 99.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 99.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 99.67500305 16.35000038 l h f* Q q 1 0 0 1 99.30000305 0 cm -0.625 -0.25 m 327.875 -0.25 l 327.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 98.92500305 0.75 l 98.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 99.92500305 -0.25 l 99.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 99.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 99.67500305 16.35000038 l h f* Q q 1 0 0 1 99.30000305 0 cm -0.625 -0.25 m 327.875 -0.25 l 327.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 98.92500305 0.75 l 98.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 99.92500305 -0.25 l 99.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 99.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 99.67500305 16.35000038 l h f* Q q 1 0 0 1 99.30000305 0 cm -0.625 -0.25 m 327.875 -0.25 l 327.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 98.92500305 0.75 l 98.92500305 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 99.92500305 -0.25 l 99.92500305 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 99.67500305 0.75 m 426.17498779 0.75 l 426.17498779 156.75 l 99.67500305 156.75 l h f* Q q 1 0 0 1 99.30000305 0 cm -0.625 -0.25 m 327.875 -0.25 l 327.875 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Ub)1(iquitin-conju)-1(g)1(ating)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.26000214 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.76000214 11.72200012 Tm [(E2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.98600006 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.48600006 11.72200012 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.86700439 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.36700439 11.72200012 Tm [(var)1(i)-1(a)1(n)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.77099609 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.27099609 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.7440033 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.2440033 11.72200012 Tm [(constitut)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.29699707 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.79699707 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.77200317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.27200317 11.72200012 Tm [(dist)1(in)-1(ct)] TJ ET EMC /P <> BDC BT 1 0 0 -1 314.75 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(subf)1(amily)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.54199982 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.04199982 27.3220005 Tm [(wit)1(hin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.37799835 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.87799835 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.8789978 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.3789978 27.3220005 Tm [(E2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.60500336 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.10500336 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.41200256 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.91200256 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.16000366 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.66000366 27.3220005 Tm [(They)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.23100281 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.73100281 27.3220005 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.07800293 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.57800293 27.3220005 Tm [(seque)-1(nce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.42498779 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.92498779 27.3220005 Tm [(similarit)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 312.63198853 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.07499981 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.57499981 42.92200089 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.73400116 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.23400116 42.92200089 Tm [(ubiquitin-)1(c)-1(onjugat)1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.32099915 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.82099915 42.92200089 Tm [(en)-1(z)1(y)-1(mes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.36799622 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.86799622 42.92200089 Tm [(but)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.51499939 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.01499939 42.92200089 Tm [(lack)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.79800415 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.29800415 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.29899597 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.79899597 42.92200089 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.87600708 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.37600708 42.92200089 Tm [(cy)-1(st)1(e)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 58.52199936 Tm [(residue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.11899948 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.61899948 58.52199936 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.8409996 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.34100342 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.90200043 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.40200043 58.52199936 Tm [(critic)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.37799835 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.87799835 58.52199936 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.15599823 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.65599823 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.65699768 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.15699768 58.52199936 Tm [(cata)1(l)-1(yt)1(i)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.39199829 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.89199829 58.52199936 Tm [(activit)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.36399841 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.86399841 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.70599365 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.20599365 58.52199936 Tm [(E2s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.76499939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.26499939 58.52199936 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.07199097 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.57199097 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.8789978 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.3789978 58.52199936 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(nc)-1(o)1(ded)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.40100098 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.90100098 74.12200165 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.4129982 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.9129982 74.12200165 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.3690033 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.8690033 74.12200165 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.38500214 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.88500214 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.44599915 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.94599915 74.12200165 Tm [(located)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.76699829 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.26699829 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.20799255 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.70799255 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.70899963 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.20899963 74.12200165 Tm [(nuc)-1(leu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.0269928 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.5269928 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.80400085 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.30400085 74.12200165 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.33799744 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.83799744 74.12200165 Tm [(cause)] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.14401245 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.64401245 74.12200165 Tm [(tr)1(ansc)-1(ri)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(pt)1(ional)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.13299942 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.63299942 89.72200012 Tm [(activat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.58300018 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.08300018 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.92500305 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.42500305 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.4260025 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.9260025 89.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.96699524 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.46699524 89.72200012 Tm [(FOS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.7769928 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.2769928 89.72200012 Tm [(pro)1(to-)1(onc)-1(o)1(gen)-1(e.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.33599854 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.83599854 89.72200012 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.83500671 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.33499146 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.89599609 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.39599609 89.72200012 Tm [(th)1(ought)] TJ ET EMC /P <> BDC BT 1 0 0 -1 303.20901489 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.70901489 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 316.78399658 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.85400009 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.35400009 105.3219986 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.72299957 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.22299957 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.16400146 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.66400146 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.66500092 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.16500092 105.3219986 Tm [(control)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.85199738 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.35199738 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.19400024 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.69400024 105.3219986 Tm [(dif)1(fe)-1(r)1(e)-1(nt)1(i)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.02000427 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.52000427 105.3219986 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.03199768 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.53199768 105.3219986 Tm [(alt)1(e)-1(ring)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.49499512 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.99499512 105.3219986 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.40499878 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.90499878 105.3219986 Tm [(cy)-1(cle)] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.19699097 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.69699097 105.3219986 Tm [(beh)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(avio)1(r.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.41799927 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.91799927 120.92199707 Tm [(Alt)1(e)-1(rna)1(tivel)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.7990036 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.2990036 120.92199707 Tm [(splice)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.37999725 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.87999725 120.92199707 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.80200195 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.30200195 120.92199707 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.87199402 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.37199402 120.92199707 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.71400452 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.21400452 120.92199707 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.58599854 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.08599854 120.92199707 Tm [(isof)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.59899998 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.09900093 136.52200317 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.44599915 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.94599915 136.52200317 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.45299911 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.95300293 136.52200317 Tm [(described)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.93800354 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.43800354 136.52200317 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.71600342 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.21600342 136.52200317 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.67199707 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.17199707 136.52200317 Tm [(gene)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.85400391 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.35400391 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.6309967 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.1309967 136.52200317 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.50300598 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.00300598 136.52200317 Tm [(pseudog)1(e)-1(nes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 297.73001099 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.23001099 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.07199097 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.57199097 136.52200317 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(his)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.10299969 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.60300064 152.12199402 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.11899948 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.61899948 152.12199402 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.9659996 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.46600342 152.12199402 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.97299957 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.47299957 152.12199402 Tm [(identified.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.57000732 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.07000732 152.12199402 Tm [(Co-)1(tra)1(n)-1(script)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.28999329 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.78999329 152.12199402 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.63200378 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.13200378 152.12199402 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.58799744 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.08799744 152.12199402 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.60400391 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.10400391 152.12199402 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.38101196 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.88101196 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 309.88198853 152.12199402 Tm [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 99.30000305 0.75 m 99.30000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 99.30000305 17.10000038 m 99.30000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 99.30000305 33.45000076 m 99.30000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 99.30000305 49.80000305 m 99.30000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 99.30000305 66.15000153 m 99.30000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 99.30000305 82.5 m 99.30000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 99.30000305 98.84999847 m 99.30000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 99.30000305 115.19999695 m 99.30000305 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 271.57501221 m 426.92498779 271.57501221 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ?? 丰满少妇被猛烈进入,丰满女老板BD高清,日韩国产成人无码AV在线,日本免费人成在线观看网站 ľ| Ϫ| | ˳| | | | | ڰ| | ɽ| | ¡| | ɽ| | | ٳ| | | Ͼ| ˳| ɽʡ| | ²| | | | | | | пǰ| | | ƽ| | | | ֦| | ɣֲ| http://444 http://444 http://444 http://444 http://444 http://444