%PDF-1.5 %?1 0 obj <> endobj 2 0 obj <>/Metadata 113 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /P <> BDC q 1 0 0 1 94.75 35.44999695 cm q 205.5 0 0 -50 0 50 cm /X1 Do Q Q EMC /P <> BDC q 1 0 0 1 371 28.19999695 cm q 117.34999847 0 0 -50.60000229 0 50.60000229 cm /X2 Do Q Q EMC /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 22.98600006 l -90 22.98600006 l h W n BT /FAAAAJ 9 Tf 1 0 0 -1 0 9.56900024 Tm 0 g [( )] TJ ET Q EMC q 1 0 0 1 90 72 cm /P <> BDC BT /FAAABC 22 Tf 1 0 0 -1 33.95500183 23.11899948 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.29100037 54.8769989 Tm /GS2 gs 0 g [(UB)1(E2W)] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 156.30499268 54.8769989 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABC 22 Tf 1 0 0 -1 333.00900269 54.8769989 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 78 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(UBE2W)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 97.86299896 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 181.86300659 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 111.53900146 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(UBE2W)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.23799896 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.61199951 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.81399536 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.18800354 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.16799927 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.54200745 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.01600647 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 145.07800293 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(UBC16)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.87400055 12.82499981 Tm [(UBC-16)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.77900696 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 178.61700439 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 212.15600586 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 273.63400269 cm /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 301.57299805 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.15999985 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.5340004 12.55799961 Tm [(length)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.6609993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.03499985 12.55799961 Tm [(fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.3259964 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.69999695 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.08200073 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 330.51199341 cm /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 358.45098877 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 386.39001465 cm /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 414.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 97.42500305 0.75 l 97.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 98.42500305 -0.25 l 98.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 98.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 98.17500305 16.35000038 l h f* Q q 1 0 0 1 97.80000305 0 cm -0.625 -0.25 m 329.375 -0.25 l 329.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ubiquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.68099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.18099976 11.72200012 Tm [(conj)-1(ug)1(ating)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.69400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.19400024 11.72200012 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.57499695 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.07499695 11.72200012 Tm [(E2W)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.45899963 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.95899963 11.72200012 Tm [(\(put)1(ative\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.17100525 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 97.42500305 0.75 l 97.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 98.42500305 -0.25 l 98.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 98.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 98.17500305 16.35000038 l h f* Q q 1 0 0 1 97.80000305 0 cm -0.625 -0.25 m 329.375 -0.25 l 329.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(UBC16)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.10899925 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.60900116 11.72200012 Tm [(UBC-16)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.44499969 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 97.42500305 0.75 l 97.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 98.42500305 -0.25 l 98.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 98.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 98.17500305 16.35000038 l h f* Q q 1 0 0 1 97.80000305 0 cm -0.625 -0.25 m 329.375 -0.25 l 329.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q96)-1(B0)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.0929985 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 97.42500305 0.75 l 97.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 98.42500305 -0.25 l 98.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 98.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 98.17500305 16.35000038 l h f* Q q 1 0 0 1 97.80000305 0 cm -0.625 -0.25 m 329.375 -0.25 l 329.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(16)-1(32)-1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 97.42500305 0.75 l 97.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 98.42500305 -0.25 l 98.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 98.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 98.17500305 16.35000038 l h f* Q q 1 0 0 1 97.80000305 0 cm -0.625 -0.25 m 329.375 -0.25 l 329.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 97.42500305 0.75 l 97.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 98.42500305 -0.25 l 98.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 98.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 98.17500305 16.35000038 l h f* Q q 1 0 0 1 97.80000305 0 cm -0.625 -0.25 m 329.375 -0.25 l 329.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 97.42500305 0.75 l 97.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 98.42500305 -0.25 l 98.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 98.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 98.17500305 16.35000038 l h f* Q q 1 0 0 1 97.80000305 0 cm -0.625 -0.25 m 329.375 -0.25 l 329.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 97.42500305 0.75 l 97.42500305 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 98.42500305 -0.25 l 98.42500305 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 98.17500305 0.75 m 426.17498779 0.75 l 426.17498779 109.94999695 l 98.17500305 109.94999695 l h f* Q q 1 0 0 1 97.80000305 0 cm -0.625 -0.25 m 329.375 -0.25 l 329.375 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(nuc)-1(lear-lo)1(c)-1(alized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.76400757 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.26400757 11.72200012 Tm [(ubiquitin-)1(c)-1(onjugat)1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.35101318 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.85101318 11.72200012 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.23199463 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.73199463 11.72200012 Tm [(\(E)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(2\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.2840004 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.7840004 27.3220005 Tm [(th)1(at,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.17300034 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.67300034 27.3220005 Tm [(along)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.06700134 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.56700134 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.96299744 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.46299744 27.3220005 Tm [(ubiquitin-)1(ac)-1(t)1(ivating)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.022995 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.522995 27.3220005 Tm [(\(E1\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.76100159 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.26100159 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.53799438 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.03799438 27.3220005 Tm [(ligat)1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.61000061 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.10998535 27.3220005 Tm [(\(E3\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.34799194 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.84799194 27.3220005 Tm [(en)-1(z)1(y)-1(mes,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 316.56100464 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(coord)1(i)-1(na)1(tes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.69100189 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.19100189 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.19200134 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.69200134 42.92200089 Tm [(ad)1(dition)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.59100342 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.09100342 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.93299866 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.43299866 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.40800476 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.90800476 42.92200089 Tm [(ubiquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.58900452 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.08900452 42.92200089 Tm [(moiety)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.86199951 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.36199951 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.43699646 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.93699646 42.92200089 Tm [(existing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.2170105 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.7170105 42.92200089 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 303.35598755 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.85598755 42.92200089 Tm [(Th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 58.52199936 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.11299896 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61299896 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.91999817 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.41999817 58.52199936 Tm [(pro)1(motes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.10699463 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.60699463 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.60800171 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.10800171 58.52199936 Tm [(ubiquitinat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.77900696 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.27900696 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.1210022 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.6210022 58.52199936 Tm [(Fanc)-1(o)1(n)-1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.09899902 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.59899902 58.52199936 Tm [(anemia)] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.0289917 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.5289917 58.52199936 Tm [(co)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(mpleme)-1(nt)1(atio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.11100006 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.61100006 74.12200165 Tm [(gr)1(oup)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.81999969 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.31999969 74.12200165 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.79299927 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.29299927 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.57000732 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.07000732 74.12200165 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.24099731 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.74099731 74.12200165 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.59500122 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.09500122 74.12200165 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.05599976 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.55599976 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.49699402 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.99700928 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.99798584 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.49798584 74.12200165 Tm [(repair)] TJ ET EMC /P <> BDC BT 1 0 0 -1 303.59500122 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 308.09500122 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 316.93701172 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.50499916 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.00499916 89.72200012 Tm [(da)1(mage.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.17399979 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.6740036 89.72200012 Tm [(There)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.52400208 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.08499908 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.58499908 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.55999756 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.05999756 89.72200012 Tm [(pseudog)1(e)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.6210022 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.1210022 89.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.39900208 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.89900208 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.35499573 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.85499573 89.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.3710022 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.8710022 89.72200012 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.13900757 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.63900757 89.72200012 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 309.43399048 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.93399048 89.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 2.16700006 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.66699982 105.3219986 Tm [(Alt)1(e)-1(rna)1(tive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.38999939 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.88999939 105.3219986 Tm [(splicin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.80500031 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.30500031 105.3219986 Tm [(results)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.47399902 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.97399902 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.91499329 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.41499329 105.3219986 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.78700256 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.28700256 105.3219986 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.20899963 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.70899963 105.3219986 Tm [(var)1(i)-1(a)1(n)-1(t)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.44500732 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 97.80000305 0.75 m 97.80000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 97.80000305 17.10000038 m 97.80000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 97.80000305 33.45000076 m 97.80000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 97.80000305 49.80000305 m 97.80000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 97.80000305 66.15000153 m 97.80000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 97.80000305 82.5 m 97.80000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 97.80000305 98.84999847 m 97.80000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 97.80000305 115.19999695 m 97.80000305 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q q 1 0 0 1 0 639.47900391 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ?? 丰满少妇被猛烈进入,丰满女老板BD高清,日韩国产成人无码AV在线,日本免费人成在线观看网站 | | | ʯ| | | | °Ͷ| ͩ®| | | | | | ֽ| | «Ϫ| | Ǹ| | ³ƶ| | ҳ| | ţ| | »| | ī| Ӻ| ˼é| Ӧñر| | ˼| ɽʡ| Ȩ| ɽ| ͷ| | | Դ| http://444 http://444 http://444 http://444 http://444 http://444