%PDF-1.5 %?1 0 obj <> endobj 2 0 obj <>/Metadata 113 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /P <> BDC q 1 0 0 1 94.75 35.44999695 cm q 205.5 0 0 -50 0 50 cm /X1 Do Q Q EMC /P <> BDC q 1 0 0 1 371 28.19999695 cm q 117.34999847 0 0 -50.60000229 0 50.60000229 cm /X2 Do Q Q EMC /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 22.98600006 l -90 22.98600006 l h W n BT /FAAAAJ 9 Tf 1 0 0 -1 0 9.56900024 Tm 0 g [( )] TJ ET Q EMC q 1 0 0 1 90 72 cm /P <> BDC BT /FAAABC 22 Tf 1 0 0 -1 33.95500183 23.11899948 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.77899933 54.8769989 Tm /GS2 gs 0 g [(TNFAI)1(P)-1(8)] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 160.81599426 54.8769989 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABC 22 Tf 1 0 0 -1 337.51998901 54.8769989 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 78 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.25 12.82499981 Tm [(TNFAIP)1(8)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 107.06099701 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 191.06100464 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 111.53900146 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TNFAIP)1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.18599701 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.55999756 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.76199341 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.13600159 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.11599731 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.49000549 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.96400452 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 145.07800293 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(NDED;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.63400269 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.00800323 12.82499981 Tm [(GG2-1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.9240036 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.29799652 12.82499981 Tm [(SC)-1(CS2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.27600098 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.6499939 12.82499981 Tm [(SC)-1(C-S)-1(2)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.84199524 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.21600342 12.82499981 Tm [(MDC-)-1(3)1(.)-1(13)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.08200073 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 178.61700439 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 212.15600586 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 273.63400269 cm /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 301.57299805 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.15999985 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.5340004 12.55799961 Tm [(length)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.6609993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.03499985 12.55799961 Tm [(fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.3259964 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.69999695 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.08200073 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 330.51199341 cm /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 358.45098877 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 386.39001465 cm /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 414.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 110.97499847 0.75 l 110.97499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 111.97499847 -0.25 l 111.97499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.72499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 111.72499847 16.35000038 l h f* Q q 1 0 0 1 111.34999847 0 cm -0.625 -0.25 m 315.82501221 -0.25 l 315.82501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(tumor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.48999977 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.98999977 11.72200012 Tm [(ne)-1(crosis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.04100037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.54100037 11.72200012 Tm [(fa)1(c)-1(t)1(or,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.82700348 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.32700348 11.72200012 Tm [(alph)1(a-induce)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.47399902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.97399902 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.28100586 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.78100586 11.72200012 Tm [(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.05900574 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 110.97499847 0.75 l 110.97499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 111.97499847 -0.25 l 111.97499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.72499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 111.72499847 16.35000038 l h f* Q q 1 0 0 1 111.34999847 0 cm -0.625 -0.25 m 315.82501221 -0.25 l 315.82501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(NDED)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.14299965 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.64300156 11.72200012 Tm [(GG)1(2)-1(-)1(1)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.64400101 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.14399719 11.72200012 Tm [(SCCS2)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.01799774 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.51799774 11.72200012 Tm [(SCC-S2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.28599548 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.78599548 11.72200012 Tm [(MDC-)1(3)-1(.)1(1)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.34899902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 110.97499847 0.75 l 110.97499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 111.97499847 -0.25 l 111.97499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.72499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 111.72499847 16.35000038 l h f* Q q 1 0 0 1 111.34999847 0 cm -0.625 -0.25 m 315.82501221 -0.25 l 315.82501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(O95)-1(37)-1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 110.97499847 0.75 l 110.97499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 111.97499847 -0.25 l 111.97499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.72499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 111.72499847 16.35000038 l h f* Q q 1 0 0 1 111.34999847 0 cm -0.625 -0.25 m 315.82501221 -0.25 l 315.82501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(07)-1(01)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 110.97499847 0.75 l 110.97499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 111.97499847 -0.25 l 111.97499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.72499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 111.72499847 16.35000038 l h f* Q q 1 0 0 1 111.34999847 0 cm -0.625 -0.25 m 315.82501221 -0.25 l 315.82501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 110.97499847 0.75 l 110.97499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 111.97499847 -0.25 l 111.97499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.72499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 111.72499847 16.35000038 l h f* Q q 1 0 0 1 111.34999847 0 cm -0.625 -0.25 m 315.82501221 -0.25 l 315.82501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 110.97499847 0.75 l 110.97499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 111.97499847 -0.25 l 111.97499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.72499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 111.72499847 16.35000038 l h f* Q q 1 0 0 1 111.34999847 0 cm -0.625 -0.25 m 315.82501221 -0.25 l 315.82501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 110.97499847 0.75 l 110.97499847 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 111.97499847 -0.25 l 111.97499847 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.72499847 0.75 m 426.17501831 0.75 l 426.17501831 78.75 l 111.72499847 78.75 l h f* Q q 1 0 0 1 111.34999847 0 cm -0.625 -0.25 m 315.82501221 -0.25 l 315.82501221 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Acts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.36499977 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.86499977 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.00600052 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.50600052 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.48099899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.98099899 11.72200012 Tm [(ne)-1(g)1(ative)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.94300079 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.44300079 11.72200012 Tm [(mediat)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.62000275 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.11999512 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.96200562 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46200562 11.72200012 Tm [(ap)1(opt)1(osis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.45599365 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.95599365 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.23300171 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.73300171 11.72200012 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.90400696 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.40400696 11.72200012 Tm [(play)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.28500366 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.78500366 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.76000977 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.26000977 11.72200012 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.92001343 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.42001343 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.36099243 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.86099243 11.72200012 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(umor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.13699913 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.63699913 27.3220005 Tm [(pro)1(gression.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.0039978 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.5039978 27.3220005 Tm [(Suppresses)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.88800049 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.38800049 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.38900757 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.88900757 27.3220005 Tm [(TNF-mediated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.92199707 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.42199707 27.3220005 Tm [(ap)1(opt)1(osis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.41598511 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.91598511 27.3220005 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.42800903 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.92800903 27.3220005 Tm [(inhib)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(iting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.44599915 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.94599915 42.92200089 Tm [(caspa)1(se)-1(-)1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.76599884 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.26599884 42.92200089 Tm [(activit)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.73799896 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.23799896 42.92200089 Tm [(but)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.88500214 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.38500214 42.92200089 Tm [(not)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.0059967 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.5059967 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.50700378 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.00700378 42.92200089 Tm [(pro)1(c)-1(essing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.56300354 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.06300354 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.90499878 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.40499878 42.92200089 Tm [(pro)1(c)-1(a)1(spase-8,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.29800415 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.79800415 42.92200089 Tm [(sub)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(seque)-1(nt)1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.73899841 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.23899841 58.52199936 Tm [(resulting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.94000244 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.44000244 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.3809967 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.8809967 58.52199936 Tm [(inhibitio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.91700745 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.41700745 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.25900269 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.75900269 58.52199936 Tm [(BID)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.90699768 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.40699768 58.52199936 Tm [(cl)-1(eava)1(ge)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.95799255 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.45799255 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.73500061 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.23500061 58.52199936 Tm [(caspa)1(se)-1(-)1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.05499268 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.55499268 58.52199936 Tm [(acti)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(vat)1(ion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.88100052 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.34999847 0.75 m 111.34999847 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.34999847 17.10000038 m 111.34999847 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.34999847 33.45000076 m 111.34999847 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.34999847 49.80000305 m 111.34999847 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.34999847 66.15000153 m 111.34999847 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.34999847 82.5 m 111.34999847 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.34999847 98.84999847 m 111.34999847 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.34999847 115.19999695 m 111.34999847 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.55001831 0.75 m 426.55001831 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92501831 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17501831 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17501831 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17501831 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17501831 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17501831 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17501831 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17501831 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 193.57499695 m 426.92501831 193.57499695 l S Q Q q 1 0 0 1 0 608.2789917 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ?? 丰满少妇被猛烈进入,丰满女老板BD高清,日韩国产成人无码AV在线,日本免费人成在线观看网站 Ϳ| | ƽ| Ƥ| | ĵ| | | | ˮ| | | | | е| | | | | | ղ| ɽ| | | | ˮ| | ͭ| ɽ| | | | | ƶ| | ؼ| | | | ƽ| Զ| http://444 http://444 http://444 http://444 http://444 http://444