%PDF-1.5 %?1 0 obj <> endobj 2 0 obj <>/Metadata 124 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /P <> BDC q 1 0 0 1 94.75 35.44999695 cm q 205.5 0 0 -50 0 50 cm /X1 Do Q Q EMC /P <> BDC q 1 0 0 1 371 28.19999695 cm q 117.34999847 0 0 -50.60000229 0 50.60000229 cm /X2 Do Q Q EMC /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 22.98600006 l -90 22.98600006 l h W n BT /FAAAAJ 9 Tf 1 0 0 -1 0 9.56900024 Tm 0 g [( )] TJ ET Q EMC /Artifact <> BDC q 1 0 0 1 90 769.66699219 cm -90 0 m 505.29998779 0 l 505.29998779 22.63299942 l -90 22.63299942 l h W n Q EMC q 1 0 0 1 90 72 cm /P <> BDC BT /FAAABC 22 Tf 1 0 0 -1 24.62100029 23.11899948 Tm /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT 1 0 0 -1 72.3710022 23.67700005 Tm /GS2 gs 0 g [(C9orf)-1(1)1(16)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.2250061 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 166.2250061 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABC 22 Tf 1 0 0 -1 342.9289856 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 93.59999847 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(C9orf116)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.28800201 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 107.53800201 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 191.53799438 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 127.13899994 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(C9orf116)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.28800201 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.66200256 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.86399841 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.23800659 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.21800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.59199524 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.06599426 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 160.67799377 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(chromos)-1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.33499908 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.70899963 12.82499981 Tm [(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.03099823 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.40499878 12.82499981 Tm [(op)-1(e)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.19999695 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.57400513 12.82499981 Tm [(re)1(ad)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.87399292 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.2480011 12.82499981 Tm [(frame)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.75500488 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.1289978 12.82499981 Tm [(116;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.90400696 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.27799988 12.82499981 Tm [(PIERCE1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.0329895 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.40701294 12.82499981 Tm [(RbE)-1(ST47)] TJ ET EMC /P <> BDC BT 1 0 0 -1 314.33599854 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 194.21699524 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 227.7559967 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAJ 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 261.29501343 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w 0 G [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABC 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 289.23400879 cm /P <> BDC BT /FAAABC 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 317.17300415 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAJ 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(1-92)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.29499817 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.33000183 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.3710022 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.40600586 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.83700562 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.87200928 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.36499023 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.3999939 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.08599854 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.1210022 12.04500008 Tm [(C9orf116)] TJ ET EMC /P <> BDC BT /FAAABC 9 Tf 1 0 0 -1 335.79598999 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS1 gs 0 G 0.5 w 0 0.5 m 0 28.43899918 l S Q q /GS1 gs 0 G 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q /GS1 gs 0 G 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q /GS1 gs 0 G 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 346.11199951 cm /P <> BDC BT /FAAABC 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 374.05099487 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w 0 G [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABC 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 401.98999023 cm /P <> BDC BT /FAAABC 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 429.9289856 cm q /GS2 gs 1 g 0.375 0.75 m 130.625 0.75 l 130.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.625 -0.25 l 131.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.375 16.35000038 l h f* Q q 1 0 0 1 131 0 cm -0.625 -0.25 m 296.17498779 -0.25 l 296.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.79499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.29499817 11.72200012 Tm [(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.57299805 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.07299805 11.72200012 Tm [(op)1(e)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.19499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.69499969 11.72200012 Tm [(reading)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.66700745 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.16700745 11.72200012 Tm [(fra)1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.23800659 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.73800659 11.72200012 Tm [(11)-1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.57099915 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 130.625 0.75 l 130.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.625 -0.25 l 131.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.375 16.35000038 l h f* Q q 1 0 0 1 131 0 cm -0.625 -0.25 m 296.17498779 -0.25 l 296.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(PIER)1(CE1)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.38899994 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.88899994 11.72200012 Tm [(RbE)1(ST)-1(47)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.37000275 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 130.625 0.75 l 130.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.625 -0.25 l 131.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.375 16.35000038 l h f* Q q 1 0 0 1 131 0 cm -0.625 -0.25 m 296.17498779 -0.25 l 296.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q5B)-1(N46)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.13199997 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 130.625 0.75 l 130.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.625 -0.25 l 131.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.375 16.35000038 l h f* Q q 1 0 0 1 131 0 cm -0.625 -0.25 m 296.17498779 -0.25 l 296.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(21)-1(26)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 130.625 0.75 l 130.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.625 -0.25 l 131.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.375 16.35000038 l h f* Q q 1 0 0 1 131 0 cm -0.625 -0.25 m 296.17498779 -0.25 l 296.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 130.625 0.75 l 130.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.625 -0.25 l 131.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.375 16.35000038 l h f* Q q 1 0 0 1 131 0 cm -0.625 -0.25 m 296.17498779 -0.25 l 296.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 130.625 0.75 l 130.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.625 -0.25 l 131.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.375 16.35000038 l h f* Q q 1 0 0 1 131 0 cm -0.625 -0.25 m 296.17498779 -0.25 l 296.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 130.625 0.75 l 130.625 141.1499939 l 0.375 141.1499939 l h f* Q q -0.625 -0.25 m 131.625 -0.25 l 131.625 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 0 74.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.29199982 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.375 0.75 m 426.17498779 0.75 l 426.17498779 141.1499939 l 131.375 141.1499939 l h f* Q q 1 0 0 1 131 0 cm -0.625 -0.25 m 296.17498779 -0.25 l 296.17498779 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(C9orf116)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.57699966 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.07699966 11.72200012 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.33399963 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.83399963 11.72200012 Tm [(kn)-1(o)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.65299988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.15299988 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.29399872 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.79399872 11.72200012 Tm [(PIER)1(CE1)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.18299866 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.68299866 11.72200012 Tm [(PIER)1(CE1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.90499878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.40499878 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.96600342 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.46600342 11.72200012 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.98699951 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.48699951 11.72200012 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.44799805 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.94799805 11.72200012 Tm [(p53)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.25201416 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ta)1(rget)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.97999954 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.47999954 27.3220005 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.99599838 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.49599838 27.3220005 Tm [(contribut)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.80599976 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.30599976 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.3809967 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.8809967 27.3220005 Tm [(normal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.38800049 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.88800049 27.3220005 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.39300537 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.89300537 27.3220005 Tm [(da)1(mage)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.89500427 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.39500427 27.3220005 Tm [(response)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.39199829 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.89199829 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.16900635 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.17099953 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.67099953 42.92200089 Tm [(play)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.55199814 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.05199814 42.92200089 Tm [(cru)-1(cial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.82499695 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.32499695 42.92200089 Tm [(roles)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.15100098 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.65100098 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.59200287 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.09200287 42.92200089 Tm [(mainta)1(in)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.40699768 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.90699768 42.92200089 Tm [(genomic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.3789978 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.8789978 42.92200089 Tm [(integrit)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.98399353 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.48399353 42.92200089 Tm [(ag)1(ainst)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.6499939 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(genoto)1(xic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.67499924 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.17499924 58.52199936 Tm [(st)1(re)-1(ss)1(e)-1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.00800323 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.50800323 58.52199936 Tm [(inc)-1(luding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.35800171 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.85800171 58.52199936 Tm [(UVC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.68400574 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.18400574 58.52199936 Tm [(irrad)1(iatio)1(n)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.73500061 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.23500061 58.52199936 Tm [(PIER)1(CE1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.45700073 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.95700073 58.52199936 Tm [(exists)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.70498657 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.20498657 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.3460083 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 74.12200165 Tm [(alt)1(e)-1(rnat)1(ive)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.20400238 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.70400238 74.12200165 Tm [(splice)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.78500366 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.28500366 74.12200165 Tm [(isof)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.44500732 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.94500732 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.22200012 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.72200012 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.28300476 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.78300476 74.12200165 Tm [(predo)1(min)-1(a)1(n)-1(t)1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.95899963 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.45899963 74.12200165 Tm [(express)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.86299992 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.36299992 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.30400085 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.80400085 89.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.84500122 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.34500122 89.72200012 Tm [(small)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.70899963 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.20899963 89.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.6190033 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.1190033 89.72200012 Tm [(lun)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.36299896 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.86300659 89.72200012 Tm [(canc)-1(er.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.1190033 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.6190033 89.72200012 Tm [(PIER)1(CE1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.84100342 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.34100342 89.72200012 Tm [(kn)-1(o)1(c)-1(kdow)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05200195 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.55200195 89.72200012 Tm [(induc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.27200031 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.77200031 105.3219986 Tm [(do)1(wn-regulat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.02700043 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.52700043 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.3690033 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.8690033 105.3219986 Tm [(pro)1(apo)1(pto)1(tic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.30400085 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.80400085 105.3219986 Tm [(gene)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.48599243 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.98599243 105.3219986 Tm [(inc)-1(luding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.83599854 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.33599854 105.3219986 Tm [(Ei24)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.40100098 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.90100098 105.3219986 Tm [(Ap)1(af)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.27799988 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.77799988 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.05500031 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.55500031 120.92199707 Tm [(PTEN,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.65200043 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.15200043 120.92199707 Tm [(sugg)1(e)-1(st)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.7009964 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.2009964 120.92199707 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.42300415 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.92300415 120.92199707 Tm [(PIER)1(CE1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.14500427 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.64500427 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.20599365 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.70599365 120.92199707 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.68099976 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.18099976 120.92199707 Tm [(pro)1(apo)1(pto)1(tic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.61599731 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.11599731 120.92199707 Tm [(gene)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.79800415 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.29800415 120.92199707 Tm [(I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.35299993 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.85300016 136.52200317 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.41399956 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.91399956 136.52200317 Tm [(helpful)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.76599884 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.26599884 136.52200317 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.54399872 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.04399872 136.52200317 Tm [(in-dept)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.38400269 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.88400269 136.52200317 Tm [(understa)1(n)-1(d)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.77000427 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.27000427 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.11199951 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.61199951 136.52200317 Tm [(p53)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.91600037 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.41600037 136.52200317 Tm [(pa)1(thw)1(ays)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.04299927 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.54299927 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.82000732 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.32000732 136.52200317 Tm [(t)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 255.59999084 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131 0.75 m 131 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131 17.10000038 m 131 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131 33.45000076 m 131 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131 49.80000305 m 131 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131 66.15000153 m 131 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131 82.5 m 131 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131 98.84999847 m 131 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131 115.19999695 m 131 255.59999084 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 255.59999084 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 255.97497559 m 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