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      • C4BPB 抗原(重组蛋白)

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        • 目录号 : TW3918
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      中文名称: C4BPB 抗原(重组蛋白)

      英文名称: C4BPB Antigen (Recombinant Protein)

      别     名: complement component 4 binding protein beta; C4BP

      储     存: 冷冻(-20℃)

      相关类别:抗原

      概    述

      Fusion protein corresponding to a region derived from 21-251 amino acids of human C4BPB

      技术规格

      Full name:

      complement component 4 binding protein beta

      Synonyms:

      C4BP

      Swissprot:

      P20851

      Gene Accession:

      BC005378

      Purity:

      >85%, as determined by Coomassie blue stained SDS-PAGE

      Expression system:

      Escherichia coli

      Tags:

      His tag C-Terminus, GST tag N-Terminus

      Background:

      This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants.



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