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      • C1QTNF3 抗原(重组蛋白)

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        • 品牌 : 通蔚生物
        • 目录号 : TW3879
        • 应用 : 仅供科研使用
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        • 货期 : 现货
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      中文名称: C1QTNF3 抗原(重组蛋白)

      英文名称: C1QTNF3 Antigen (Recombinant Protein)


      别      名: C1q and tumor necrosis factor related protein 3; CORS; CORCS; CTRP3; CORS26; C1ATNF3; CORS-26


      相关类别: 抗原


      储    存: 冷冻(-20℃)



      Fusion protein corresponding to a region derived from 190-319 amino acids of human C1QTNF3

      技术规格

      Full name:

      C1q and tumor necrosis factor related protein 3

      Synonyms:

      CORS; CORCS; CTRP3; CORS26; C1ATNF3; CORS-26

      Swissprot:

      Q9BXJ4

      Gene Accession:

      BC120990

      Purity:

      >85%, as determined by Coomassie blue stained SDS-PAGE

      Expression system:

      Escherichia coli

      Tags:

      His tag C-Terminus, GST tag N-Terminus

      Background:

      C1qTNF3 (Complement C1q TNF-related protein 3/CTRP3; also CORS26 and cartonectin) is a 30-32 kDa, secreted member of the C1q and TNF-related protein (CTRP) superfamily of molecules. It is expressed by a wide variety of cells, including smooth muscle cells, fibroblasts, adipocytes, monocytes and proliferating chondrocytes. C1qTNF3 is an anti-inflammatory agent that apparently blocks LPS activation of mononuclear cells. It also has marked proliferative activity on diverse cell types such as vascular smooth muscle, chrondrocytes, and endothelium. Finally, C1qTNF3 is known to act on hepatocytes and suppress hepatocyte gluconeogenesis. Mature human C1qTNF3 is 224 amino acids (aa) in length (aa 23-246). It possesses an N-terminal collagen-like domain (aa 51-113) followed by a C-terminal globular region (aa 113-246). C1qTNF3 is monomeric when intracellular, but forms a 90 kDa homotrimer plus higher-order oligomer when secreted. There are at least two potential isoform variants. One is 40-42 kDa, glycosylated, and contains a 73 aa insertion after Glu28, while a second shows concurrent deletions of aa 46?69 and 82-105. The longer 40 kDa isoform is reported to form heterotrimers and oligomers with the standard 30 kDa isoform. This has the effect of protecting the standard isoform from proteolysis. Over aa 24-246, human C1qTNF3 shares 99% aa sequence identity with mouse C1qTNF3.






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