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      • THEM5抗原(重组蛋白)

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        • 品牌 : 通蔚生物
        • 目录号 : TW20037
        • 应用 : 仅供科研使用
        • 保存条件 : 低温保存
        • 货期 : 现货
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      中文名称: THEM5抗原(重组蛋白)

      英文名称: THEM5 Antigen (Recombinant Protein)

      别     名:  ACOT15

      储     存:  冷冻(-20℃)

      相关类别: 抗原

      概     述

      Full length fusion protein

      技术规格
       

      Full name:

      thioesterase superfamily member 5

      Synonyms:

      ACOT15

      Swissprot:

      Q8N1Q8

      Gene Accession:

      BC112239

      Purity:

      >85%, as determined by Coomassie blue stained SDS-PAGE

      Expression system:

      Escherichia coli

      Tags:

      His tag C-Terminus, GST tag N-Terminus

      Background:

      THEM5 (thioesterase superfamily member 5) is a 247 amino acid protein that belongs to the thioesterase superfamily. The gene that encodes THEM5 contains nearly 8,000 bases and maps to human chromosome 1q21.3. Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleyl-CoA and other unsaturated long-chain fatty acid-CoA esters. Plays an important role in mitochondrial fatty acid metabolism, and in remodeling of the mitochondrial lipid cardiolipin. Required for normal mitochondrial function.



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